Missouri Road Trips
Missouri is called the "Show-Me" State, and that's exactly what it does. Show your family a good time with a road trip through Missouri, where you'll find local eateries, breweries, award-winning barbeque and endless outdoor adventures. Rent a car from Enterprise and start your journey today!
Missouri Road Trips
Drive From Chicago to St. Louis
Looking to go from Chicago to St. Louis? Driving may be your best option. Our neighborhood locations are open and ready to serve you with curbside pickup and modified cleaning procedures.
Drive From St. Louis to Chicago
Looking to go from St. Louis to Chicago? Driving may be your best option. Our neighborhood locations are open and ready to serve you with curbside pickup and modified cleaning procedures.
Drive From St. Louis to Indianapolis
Looking to go from St. Louis to Indianapolis? Driving may be your best option. Our neighborhood locations are open and ready to serve you with curbside pickup and modified cleaning procedures.
Drive From St. Louis to Kansas City
Looking to go from St. Louis to Kansas City? Driving may be your best option. Our neighborhood locations are open and ready to serve you with curbside pickup and modified cleaning procedures.
Drive From St. Louis to Little Rock
Looking to go from St. Louis to Little Rock? Driving may be your best option. Our neighborhood locations are open and ready to serve you with curbside pickup and modified cleaning procedures.
Drive From St. Louis to Milwaukee
Looking to go from St. Louis to Milwaukee? Driving may be your best option. Our neighborhood locations are open and ready to serve you with curbside pickup and modified cleaning procedures.
Drive From St. Louis to Nashville
Looking to go from St. Louis to Nashville? Driving may be your best option. Our neighborhood locations are open and ready to serve you with curbside pickup and modified cleaning procedures.
Drive From St. Louis to Pensacola
Looking to go from St. Louis to Pensacola? Driving may be your best option. Our neighborhood locations are open and ready to serve you with curbside pickup and modified cleaning procedures.
Drive From St. Louis to the Ozarks
Looking to go from St. Louis to the Ozarks? Driving may be your best option. Our neighborhood locations are open and ready to serve you with curbside pickup and modified cleaning procedures.
Missouri Road Trips
Find your perfect road trip destination in Missouri. Take a ride with Enterprise Rent-A-Car and start your journey today!
Missouri Road Trip Inspiration
A Beginner’s Guide to Mudslinging
Pottery lessons are a fun way to relax and get creative on the Gulf Coast.
Road Trip to Witness the Bald Eagle Migration
Birdwatchers, photographers and nature lovers plan annual road trips to the Midwest to see bald eagles hunt and fish, and with a rental car from Enterprise, you can join the flock. Thousands of the big birds feed along the Missouri, Illinois and Mississippi rivers.
Echo Bluff is Gateway to Ozark Adventures
Ozark adventures are easy in an Enterprise rental car! A road trip to Missouri’s Echo Bluff State Park puts you in exactly the right place for exploring the area’s rivers, springs, caves and scenic vistas as you relax in nature.
Find Family Fun in St. Louis
Whether your kids are animal lovers, science fans or adventurers, the city has many options to explore.
Floating with Friends on Ozark Rivers
Float trips on Missouri’s crystal-clear Ozark rivers are memorable, and an Enterprise rental car makes the road trip easy. Pack the car, drive to the river of your choice, rent a canoe and launch into a place of scenic serenity any time of year.
From T-Ravs to Ted Drewes, St. Louis Is a Tasty Town
When visiting, be sure to finish a meal with a piece of gooey butter cake.
Nostalgic Route 66 Road Trip: Albuquerque to St. Louis
Choosing the “old road” opens up a world of appealing characters and beauty along the “Main Street of America.”
Nostalgic Route 66 Road Trip: St. Louis to Chicago
A weekend road trip through Illinois farmland leads to classic diners, drive-ins and big city splendor.
Top 5 Ozark Rivers to Float
After 50 years of enjoying the water, our author reveals his favorite river journeys.
See All Road Trips
Looking for more road trip ideas? Check out our Road Trip Planner and choose your next journey!
Road Trip IdeasStart A Reservation
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